Organize and Share your Electronics the way you want. Sign-Up for a free account now. It takes only 30 seconds!

Direct Determination of Fluoroacetate in Water by IC-MS

Direct Determination of Fluoroacetate in Water by IC-MS

Fluoroacetate (FA, compound 1080) is a strong metabolic poison commonly used as a rodenticide and predacide.1 Fluoroacetic acid is also an intermediate metabolite of many compounds, such as anticancer drugs 5-fluorouracil and fluoroethyl nitrosourea. Fluoroacetate is inexpensive, simple to synthesize, tasteless, and highly soluble in water. Due to the high level of toxicity when ingested,2 and no known antidotes, its use has been banned or restricted in many countries. The United States Environmental Protection Agency (U.S. EPA) has placed sodium fluoroac- etate in Toxicity Category I indicating the highest degree for acute oral toxicity. It is therefore crucial to develop a method for determination of fluoroacetic acid.

Analyses for fluoroacetate have been previously per- formed using several methods, including gas chromatography,3 HPLC,4 and fluoride ion selective electrode.5 Many of these techniques relied upon derivatization prior to analysis6-8 and lacked adequate sensitivity for low-level detection. Use of chromatographic separation with selected ion monitoring (SIM) mass spectrometry (MS) detection affords the opportunity to reliably identify this compound at trace levels in water samples.

This study undertook an investigation to quantify fluoroacetate without prior derivatization or sample pretreatment. An ion chromatography (IC) method was developed with an MS detector. A fortified drinking water matrix was prepared following U.S. EPA guidelines and used to challenge the separation and robustness of the method. Samples of fortified drinking water spiked with the analyte were injected directly. Monitoring the mass-to-charge ratio (m/z) in SIM mode on a single quadrupole instrument allowed for highly sensitive and selective analysis. Method performance parameters such as linearity, calibration range, precision, accuracy, and detection limits were determined.

Read more Here







 

More Articles to Read

Gesture Controlled Smart Home
Gesture Controlled Smart Home
Design for a Wideband, Differential Transimpedance DAC Output
Design for a Wideband, Differential Transimpedance DAC Output
Wrist thrusters let you fly through the water effortlessly
Wrist thrusters let you fly through the water effortlessly
Bertan/Spellman 225-20R HV power supply teardown
Bertan/Spellman 225-20R HV power supply teardown
Blinking Christmas Lights
Blinking Christmas Lights
Adjusting clock with alarm, hygrometer & thermometer on 1.8″ ST7735 display
Adjusting clock with alarm, hygrometer & thermometer on 1.8″ ST7735 display
Adding an “extra sense” with rangefinders
Adding an “extra sense” with rangefinders
This wireless game controller looks like a rug
This wireless game controller looks like a rug
How to run your ESP8266 for years on a battery
How to run your ESP8266 for years on a battery
Calibration of a 3-Phase Energy Meter Board on the ADE7754
Calibration of a 3-Phase Energy Meter Board on the ADE7754
Making beats on a tiny Arduino DJ controller
Making beats on a tiny Arduino DJ controller
Qinsi-QS5100 Sn63Pb37 solder profile
Qinsi-QS5100 Sn63Pb37 solder profile
Water Detection System
Water Detection System
Professional Hi-Fi 15W Tube Amplifier circuit
Professional Hi-Fi 15W Tube Amplifier circuit
This Arduino machine will judge how sick your ollies are
This Arduino machine will judge how sick your ollies are
Turn an old payphone into a boombox for ’90s hits
Turn an old payphone into a boombox for ’90s hits
Big F’n 3D printer build
Big F’n 3D printer build
Temperature alarm for boiling milk
Temperature alarm for boiling milk
QuadBot is a 3D-printable walking robot for everyone
QuadBot is a 3D-printable walking robot for everyone
MicroConverter I2C Compatible Interface
MicroConverter I2C Compatible Interface

Top


Shares